What Are The Most Effective Depression Treatments?

by | Sep 13, 2023

Depression is a chronic mental health condition that many people experience every day of their lives. Thankfully, treatments are available to help combat depression, including medication, psychotherapy, exercise, mindfulness, and TMS therapy. 

Using a combination of these treatment options often works well to relieve the debilitating symptoms of depression. Today’s blog explores these options, giving you an overview of all the tools you can utilize to manage depression. 

Medications for Depression

There are four types of antidepressants: SSRIs, SNRIs, TCAs, and MAOIs. Let’s look at these acronyms and how they help treat depression.

1. SSRIs:

SSRIs stand for selective serotonin reuptake inhibitors. SSRIs are medications that can help people with depression. They work by increasing the levels of serotonin in the brain. Serotonin is a chemical messenger that sends signals between brain nerve cells.

So, when someone is depressed, they might have low serotonin levels in their brain. SSRIs block the reabsorption, or reuptake, of serotonin into neurons, increasing serotonin concentration in the brain. And when serotonin levels increase, it can enhance mood and help alleviate depressive symptoms.

Prozac, Zoloft, and Lexapro are examples of SSRI antidepressants.

2. SNRIs:

SNRIs, or serotonin-norepinephrine reuptake inhibitors, are another medication used to treat depression. They work by affecting two neurotransmitters in the brain: serotonin and norepinephrine.

Serotonin is important for mood regulation, while norepinephrine plays a role in mood and energy levels.SNRIs, like SSRIs, block the reuptake of these neurotransmitters, which means they increase the amount of serotonin and norepinephrine available in the brain. By doing this, SNRIs can help improve mood, boost energy levels, and relieve symptoms of depression.

Effexor, Cymbalta, and Pristiq are examples of SNRI antidepressants.

3. TCAs:

TCAs, or tricyclic antidepressants, are a medication used to treat depression and other mental health conditions. They have been around for a while and were one of the earliest types of antidepressants developed.

TCAs affect the levels of certain neurotransmitters, like serotonin and norepinephrine, in the brain. They block the reuptake, or reabsorption, of these neurotransmitters by neurons. By doing this, TCAs increase the concentration of serotonin and norepinephrine in the brain, which can help improve mood and alleviate symptoms of depression. TCAs are also sometimes used to treat other conditions, such as chronic pain, migraines, and sleep disorders, because of their effects on these neurotransmitters.

Elavil, Imipramine, and Nortriptyline are examples of TCA antidepressants.

4. MAOIs:

MAOIs, or monoamine oxidase inhibitors, are a type of medication used to treat depression and certain anxiety disorders. They target an enzyme called monoamine oxidase, which breaks down neurotransmitters like serotonin, norepinephrine, and dopamine in the brain.

By inhibiting the action of monoamine oxidase, MAOIs increase the levels of these neurotransmitters in the brain. This can help improve mood, reduce anxiety, and alleviate depressive symptoms. It’s important to note that MAOIs require dietary restrictions due to potential interactions with certain foods and other medications.

To prevent complications, foods like aged cheeses, cured meats, and certain beverages like wine and beer should be avoided when taking MAOIs. Also, a healthcare professional will closely monitor the use of MAOIs, as they can have significant interactions with other medications and may cause certain side effects.

Marplan, Nardil, and Parnate are examples of MAOI antidepressants.

How Effective Are Antidepressants

How Effective Are Antidepressants?

When it comes to the effectiveness of antidepressants, it’s essential to understand that they vary from person to person. Some people may experience a significant improvement in their symptoms, while the effects may be more moderate for others.

Generally, antidepressants are effective in treating depression and improving symptoms in many individuals.

It’s also important to remember that finding the right antidepressant and dosage might require trial and error. What works for one person may not work for another, so finding the most effective option can take time.

Additionally, therapy and counseling can also play a crucial role in treating depression and may be combined with medication for better outcomes. We’ll discuss therapy options in the next section.

Pros and Cons of Taking Antidepressants

Pros of Taking Antidepressants:

  • Effectiveness: Antidepressants are effective in reducing symptoms of depression in many individuals. They can improve mood, alleviate feelings of sadness, and help regain interest in previously enjoyable activities.
  • Motivation for Lifestyle Changes: Antidepressants can provide the motivation needed to make positive lifestyle changes that may help manage depressive symptoms. By feeling better, individuals may find it easier to engage in activities like exercise, maintain a healthy diet, and seek therapy or support.

Cons of Taking Antidepressants:

  • Side Effects: Like any medication, antidepressants can cause side effects. These can vary depending on the specific medication but may include symptoms such as nausea, weight gain, sleep disturbances, or sexual dysfunction. However, it’s important to note that not everyone experiences side effects, and they are often temporary and manageable.
  • Delayed Onset: It may take several weeks or even months before the full benefits of antidepressants are felt. This delayed onset can be frustrating for individuals seeking immediate relief from their symptoms.
  • Individual Response: Everyone’s response to antidepressants can differ. While some people experience significant improvement in their symptoms, others may have a more moderate or minimal response. Finding the proper medication and dosage that works best for an individual may take time.

If you or someone you know is considering antidepressants, it’s always essential to consult with a healthcare professional. They will assess your situation and determine your best treatment plan. It’s a process, but with the right guidance and support, antidepressants can effectively manage depression. 


There are multiple types of psychotherapy, from cognitive behavioral to interpersonal therapy and more. Let’s take a closer look. 

Cognitive Behavioral Therapy (CBT):

CBT is a widely used therapy that focuses on the connection between our thoughts, feelings, and behaviors. It helps us understand how our thoughts contribute to our emotional experiences and how those emotions, in turn, impact our behaviors. Here’s a more detailed explanation: In CBT, the central idea is that our thoughts (cognitions) influence our emotions and behaviors. CBT aims to identify and change negative, unhelpful thought patterns that may contribute to depression.

In CBT, you’ll typically do the following: 

  1. Identifying Negative Thoughts: The first thing you do in CBT is to pay attention to those negative thoughts and beliefs that pop up in different situations. Sometimes, these thoughts come out of nowhere and can be pretty skewed, not reflecting reality accurately, or they bring us down. It’s important to recognize when those thoughts occur and whether they’re helpful based on objective evidence. By becoming aware of these negative thoughts, we are able to start challenging them and replacing them with more positive and realistic ones.
  2. Examining the Evidence: Once you’ve spotted those negative thoughts, the therapist will help you evaluate if they’re valid or merely playing tricks on your mind. Together, you and the therapist dive into the evidence behind those thoughts and see if they hold up in reality. By questioning and challenging these thoughts, you can start to see things from a more balanced and realistic perspective. It’s like taking a step back and being your own detective, gathering the evidence to figure out what’s true and what’s not.
  3. Developing Alternative Thoughts During this step, you start working on crafting new, positive, and realistic thoughts. It’s all about finding alternative ways to see things, considering different perspectives, and shifting your focus to the evidence that supports those positive thoughts. And remember, it’s also about challenging those negative assumptions that tend to bring you down. It’s like giving your mind a makeover, replacing the negative with the positive, and building a more optimistic outlook that aligns with reality.
  4. Behavior Experimentation: CBT is not just about talking or thinking; it involves getting out there and trying new things! You actually put your new thoughts, beliefs, and behaviors into action in real-life situations. This way, you can see how they work and what impact they have. It’s like being a scientist of your own mind, gathering real evidence to show that your new ways of thinking are valid and helpful. It’s all about trying, learning, and growing with confidence!
  5. Skill Building: In CBT, you learn useful skills that help you cope with challenges and solve problems better. It’s like building up your toolkit of strategies. The therapist might teach you relaxation techniques to help you unwind and de-stress. They might also help you become more assertive and express yourself confidently and respectfully. And hey, there might even be some social skills training to help you navigate those tricky social situations. It’s all about growing and developing the skills you need to handle whatever comes your way.
  6. Homework and Practice: CBT is a therapy that really keeps you in the game. You won’t just sit back and listen; you’ll also have some homework. The therapist may give you assignments to practice the new skills and techniques you learn during your sessions. It’s like taking those ideas out for a test drive in your everyday life. By consistently practicing, you’re actually integrating those new ways of thinking and behaving into your daily routine. It’s all about making progress and seeing positive changes that stick with you in the long run.

Psychodynamic Therapy

Psychodynamic Therapy:

Psychodynamic therapy is a type of therapy that focuses on exploring and understanding the unconscious mind. It’s all about digging deep to uncover the hidden feelings, memories, and experiences that may influence your thoughts and behaviors.

By bringing these unconscious factors to light, you gain insight into patterns and conflicts that might be causing you distress.

The therapist is like a detective, helping you connect the dots between your past and present to understand yourself better. It’s a way to dive beneath the surface and find resolution by exploring the depths of your mind.

Interpersonal Therapy (IPT):

IPT is a type of therapy that focuses on your relationships and how they impact your emotional well-being. The main goal is to improve how you communicate and relate to others, which can significantly impact your overall mental health.

The therapist will help you identify any recurring patterns or conflicts in your relationships and work with you to find healthier ways to navigate them. This therapy is all about helping you build stronger connections, resolve conflicts, and improve your social support network.

So, if you’re struggling with relationships or feeling lonely, interpersonal therapy could be just what the doctor ordered to help you thrive.

Dialectal Behavioral Therapy (DBT):

DBT is a type of therapy that’s helpful for people who struggle with intense emotions and have difficulty regulating them. DBT emphasizes finding a balance between acceptance and change.

The therapist will teach you practical skills to manage emotions, improve relationships, and cope with distressing situations.

These skills can include mindfulness techniques to help you stay present, emotion regulation strategies to calm the storm, and interpersonal effectiveness skills to enhance your communication and problem-solving abilities.

It’s like a toolkit of skills tailored to help you lead a more balanced and fulfilling life. So, if you’re looking to manage your emotions better and build healthier relationships, DBT could be a game-changer for you.

Humanistic Therapy:

Humanistic therapy is a type of therapy that focuses on the individual’s unique experiences, personal growth, and self-fulfillment. The main idea behind humanistic therapy is that every person has the capacity for growth and positive change.

The therapist will create a warm and supportive environment where you can freely explore your feelings, thoughts, and goals. They’ll help you develop a deeper understanding of yourself and your values, and encourage you to tap into your inner strengths and potential.

Humanistic therapy believes in your ability to make choices and take responsibility for your life. It’s all about fostering self-acceptance, personal growth, and creating a more meaningful and authentic life.

If you’re looking for a therapy that focuses on your unique journey and empowers you to be the best version of yourself, humanistic therapy might be just what you need.

Family Therapy:

Family therapy is a type of therapy that involves the whole family coming together to address and work through their issues as a unit. The therapist aims to improve communication, resolve conflicts, and strengthen relationships within the family system.

Family therapy recognizes that our individual well-being is often interconnected with the dynamics and relationships within our family. The therapist will provide a safe and neutral space for everyone to express their thoughts and feelings.

They’ll help identify any patterns or dynamics that might be causing distress and work with the family to find healthier ways of relating to and supporting each other.

It’s all about fostering understanding, empathy, and harmony within the family unit. So, if your family is facing challenges, conflicts, or communication issues, family therapy can be an amazing tool to bring healing and growth to everyone involved.

Group Therapy

Group Therapy:

Group therapy is where a small group of people with similar concerns or issues come together to work on their mental health with a trained therapist. Group therapy is a great way to receive support and empathy from others who are going through similar challenges.

The therapist will guide the group through exercises and discussions that promote self-awareness, self-expression, and emotional growth. Everyone in the group has the opportunity to share their experiences and perspectives and to learn from others.

Group therapy is especially helpful for those who feel isolated or disconnected, as it provides a sense of community and belonging. Additionally, seeing the progress of other group members can be highly motivating and inspiring for everyone involved.

It’s like a supportive community where everyone can work together towards a common goal of mental wellness. So, if you’re looking for a cost-effective and collaborative way to improve your mental health, group therapy might be just the thing for you.

Pros and Cons of Psychotherapy


  1. It’s effective: Psychotherapy has solid scientific backing and is proven to be effective in addressing a wide range of mental health concerns.
  2. Personalized approach: The beauty of therapy is that it’s tailored to your specific needs. It’s all about creating a treatment plan that suits you individually and helps you tackle your unique challenges and goals.
  3. Emotional support: In therapy, you get to talk about your thoughts and emotions in a safe, non-judgmental environment. Therapists provide empathy and guidance, making you feel supported throughout the process.
  4. Skill-building: Think of therapy as your mental gym. It equips you with coping mechanisms, problem-solving skills, and healthy strategies to effectively navigate life’s ups and downs.
  5. Holistic approach: Therapy goes beyond just dealing with symptoms. It delves into the underlying causes of your struggles, promoting overall well-being and personal growth.


  1. It takes time: Therapy is not a quick fix. It requires regular sessions over a period of time, which can be a commitment in terms of your schedule and availability.
  2. Financial cost: Depending on your insurance or personal finances, therapy may come with a price tag. The cost can sometimes be a barrier for those with limited resources.
  3. Emotional intensity: Opening up in therapy can bring up intense emotions. It may sometimes be challenging as you explore and process your thoughts and experiences.
  4. Availability issues: Depending on where you are and the resources in your area, finding a qualified therapist or specialized therapy approach might be limited.
  5. Effectiveness may vary: Not all therapists or therapies will be the perfect fit for you. Finding the best match that aligns with your needs and preferences might take some trial and error.

Now that we’ve discussed the different types of medications and psychotherapy that can help with depression let’s look at how exercise can also help.


Exercise has been shown to be a powerful tool in managing depression. When you exercise, your body releases chemicals called endorphins. These endorphins act as natural mood boosters and help to reduce feelings of stress and enhance overall well-being.

Regular exercise can have several benefits for individuals with depression:

  1. Increased serotonin: Exercise increases serotonin levels in the brain. Higher levels of serotonin can help alleviate feelings of sadness and improve mood.
  2. Improved sleep: Depression and sleep disturbances often go hand in hand. Engaging in regular physical activity can help regulate sleep patterns, leading to better quality sleep, which, in turn, can positively impact mood.
  3. Enhanced self-esteem: Depression often impacts self-esteem and self-worth. Regular exercise helps boost your confidence and provide a sense of accomplishment as you meet your fitness goals, leading to an overall improvement in self-esteem.
  4. Social interaction: Participating in group exercises or team sports provides opportunities for social interaction and support, which can be particularly beneficial for individuals struggling with depression.
  5. Distraction and focus: Engaging in physical activity serves as a healthy distraction from negative thoughts and rumination. It helps redirect your focus and put your mind in a more positive place.

Now, let’s talk about the types of exercises you can do to help with depression. The good news is that you have a range of options, and you can find what works best for you:

  1. Aerobic exercises: These include activities like brisk walking, jogging, cycling, swimming, or dancing. Aim for about 150 minutes of moderate-intensity aerobic exercise per week or 75 minutes of vigorous-intensity exercise.
  2. Strength training: Resistance exercises using weights, resistance bands, or body weight can help improve muscle strength and positively impact mood.
  3. Yoga and mindfulness combine physical movement with breathwork and meditation. They help reduce stress, promote relaxation, and improve overall well-being.
  4. Team sports or group activities: Joining a local sports team or group exercise classes provide social interaction while staying active.

Remember, starting slowly and gradually increasing your exercise routine’s intensity and duration is important. It’s also a good idea to consult with your healthcare provider before starting any new exercise regimen, especially if you have any underlying health conditions.



Meditation can be a powerful tool in managing and alleviating symptoms of depression. Depression often leads to a cycle of negative thoughts and emotions that can feel overwhelming. Meditation offers a way to break free from this cycle by promoting relaxation, self-awareness, and a more positive mindset. Here’s how it can help:

  1. Cultivating self-awareness: Meditation helps you develop a heightened sense of self-awareness, allowing you to observe your thoughts and emotions without judgment. By becoming aware of these thoughts and emotions, you start to distinguish between them and your true self, which is incredibly empowering.
  2. Managing negative thoughts: Through meditation, you can learn to identify negative thoughts as they arise and consciously let them go. Meditation teaches you to observe your thoughts non-judgmentally and redirect your focus to the present moment, freeing you from the grip of harmful thoughts.
  3. Enhancing emotional regulation: Meditation helps you develop emotional regulation skills by teaching you to observe emotions as temporary experiences rather than attaching yourself to them. This allows you to respond to emotions in a balanced and adaptive way, reducing their impact on your overall well-being.
  4. Stress reduction: Chronic stress contributes to developing and exacerbating depression. Meditation has been proven to reduce stress by activating the body’s relaxation response. It helps lower levels of stress hormones, such as cortisol, and promotes a state of deep relaxation, which can positively impact your mood and overall mental well-being.
  5. Mindfulness and acceptance: Depression often involves resistance and avoidance of uncomfortable emotions and experiences. You can cultivate mindfulness and acceptance through meditation, which means embracing the present moment without judgment. This empowers you to develop a more compassionate and accepting attitude toward yourself, allowing you to easily navigate difficult emotions.

To get started with meditation for depression, find a quiet and comfortable space where you won’t be disturbed. Start with just a few minutes a day, gradually increasing the duration as you become more comfortable. There are numerous guided meditation apps and online resources available that can support you in your meditation practice.

TMS Therapy for Depression

TMS therapy is another depression treatment that can really help. TMS involves using magnetic fields to stimulate specific areas of the brain associated with depression symptoms. It’s typically used when other depression treatments, such as medications or therapy, haven’t provided satisfactory results. 

During a TMS session, a specialized device generates magnetic pulses directed at specific brain regions linked to depression. These pulses stimulate the nerve cells to improve communication between different brain regions and regulate mood. The goal is to normalize the brain activity patterns associated with depression.

TMS therapy often works well for individuals who haven’t had success with medication or psychotherapy, making it a great option to look into!

TMS Therapy With Brain Health Center

If you or someone you love is struggling with depression and traditional treatments haven’t been effective, I want to encourage you to check out TMS therapy at Brain Health Center.

Our center specializes in providing TMS therapy for individuals suffering from depression. Our experienced professionals will assess your situation, determine if TMS therapy is suitable for you, and guide you through the treatment process in a caring and compassionate environment.

Don’t let depression hold you back any longer. Contact Brain Health Center or call us at 435.900.0123 to learn more about TMS therapy and how it can help you reclaim your life. We’re here to support you on your journey to mental wellness.