The Science Behind ADHD: How the Brain Functions Differently

by Brain Health Center | August 21, 2024 | Last Updated on September 8, 2025

ADHD is a condition we’ve all heard of. It affects countless kids and adults, yet there’s so much more beneath the surface, especially regarding how the brain functions differently. 

In this blog, we’re discussing how ADHD works, exploring the specific ways the brain operates that contribute to the symptoms of inattention, hyperactivity, and impulsivity. 

Whether you’re personally affected or know someone who is, understanding the neurological basis will change how you approach this disorder, from treatment to everyday interactions. 

Many people may not realize that ADHD presents differently in each individual, making it a complex and unique condition to navigate. By diving deeper into its science, we can better understand the diverse ways it impacts behavior and cognition.

Let’s get started and shed some light on the science of ADHD

What is ADHD?

ADHD, or attention-deficit/hyperactivity disorder, is a common mental health condition that affects how a person focuses, manages restlessness, or regulates impulses. It’s considered a neurodevelopmental disorder, meaning that it relates to how the brain grows and functions over time. These differences in brain activity often appear in childhood and can continue into adulthood, shaping how someone thinks, processes information, and responds to their environment. 

For people with ADHD, tasks that require substantial attention, like reading, sitting through a meeting, or following multi-step instructions, can feel unusually difficult. Research shows that ADHD is linked to differences in specific brain regions involved in executive function, particularly areas that manage focus, planning, and self-control. There’s also evidence that people with ADHD might have lower levels of neurotransmitters like dopamine, which plays a role in motivation and reward processing. 

The impact of ADHD varies widely from person to person; some people experience more trouble with focus and disorganization, while others struggle with impulse control and hyperactivity. These behavioral symptoms can affect different aspects of a person’s life, including school, work, relationships, and daily routines. However, with the proper support, many people with ADHD find ways to manage their symptoms and thrive in both structured and creative environments.

A young girl is immersed in colorful puzzle pieces, representing a playful approach to TMS therapy for ADHD.

Understanding ADHD Symptoms

ADHD is divided into two main categories: inattention and hyperactivity/impulsivity. Most people experience symptoms from both, but one category may be more prominent than the other. These symptoms can affect how someone thinks, reacts, and completes everyday tasks.

Inattention symptoms may include:

  • Losing focus during conversations or work
  • Misplacing things like keys, documents, etc
  • Difficulty organizing tasks or managing time
  • Forgetting appointments or details
  • Seeming distracted or mentally absent

Hyperactivity/impulsivity symptoms may include:

  • Feeling restless or constantly needing to move
  • Interrupting others or blurting things out
  • Trouble waiting or sitting still
  • Reacting quickly without pausing to think
  • Talking excessively or jumping between topics

ADHD symptoms can manifest in both personal and professional settings, impacting how a person functions throughout the day. Some symptoms create noticeable challenges; for others, they might be more subtle but still disruptive. 

Executive function and ADHD

Executive function refers to mental skills that help us plan, prioritize, remember instructions, and manage emotions. They are the brain’s self-management tools and play an important role in everyday activities. 

In people with ADHD, executive function tends to be less efficient, sometimes showing up as chronic disorganization, forgetfulness, trouble transitioning from one task to another, or difficulty following through with goals, even when they have the motivation. Emotional regulation can also be challenging, leading to quick frustration or difficulty calming down after stress. 

Addressing challenges with executive function skills is an incredibly important part of treating ADHD, since it helps reduce overwhelm, support better coping strategies, and allows individuals to work with their brains rather than against them. 

Diagnosing ADHD

Because ADHD is a largely subjective condition, any diagnosis depends on what a person experiences and how those symptoms affect their day-to-day life. In other words, there’s no blood test or brain scan that can confirm it. Clinicians use tools like questionnaires and interviews to understand patterns of behavior. 

For children, clinicians typically gather data from multiple sources, such as parents, teachers, and other caregivers, along with observations of behaviors both at school and at home. The goal is to identify symptoms and determine whether they’re persistent, show up in more than one environment, and affect the child. 

The process for adults relies on a combination of self-reported experiences, mental health history, and any long-standing difficulties with focus, organization, or impulse control. Adults may also be asked to recall past academic or social challenges and how those patterns have continued into adulthood.

What is the root cause of ADHD in the brain?

We don’t know for certain what exactly causes ADHD. Research suggests that ADHD is both highly hereditary—meaning that it tends to run in families—but that several non-genetic risk factors, such as low birth weight, exposure to certain toxins during pregnancy, and premature birth, might also contribute. In fact, a population study investigating the prevalence of autism and ADHD in Spanish children over a 5-year period found that gestational diabetes and a family history of mood disorders were associated with ADHD. 

At the brain level, ADHD is tied to differences in how certain areas develop and communicate, especially those involved in focus, motivation, and self-regulation. One key brain chemical—dopamine—seems to be central to this process.

Dopamine is involved in staying motivated and engaged, particularly with tasks that require long periods of attention or delayed rewards. Studies show that in people with ADHD, dopamine signaling may be less efficient, which can make routine or repetitive tasks harder to stick with.

Brain imaging has also shown that the prefrontal cortex, which is the area that helps with planning, impulse control, and decision-making, often functions differently in people with ADHD. These differences may make it harder to organize tasks, manage time, or pause before reacting.

While the causes may vary from person to person, these neurological patterns help explain why symptoms can impact so many areas of daily life. They also point us toward treatment strategies that focus on improving brain function, building helpful routines, and supporting long-term growth.

Implications for treatment and management

Effective ADHD management often involves a combination of strategies that address both brain function and day-to-day structure. The goal is to help individuals improve focus, regulate behavior, and manage potential impulsivity in ways that support their learning, relationships, and lifestyle. 

These are the most popular and effective therapies for managing ADHD:

Behavioral therapies

Behavioral therapies are usually the starting point of ADHD treatment, especially in children. These therapies focus on skill-building, such as planning, organization, and impulse control, and often involve collaboration with families and schools. 

For adults, behavioral techniques may involve strategies to improve time management, avoid distractions, and develop systems for follow-through—like task lists, scheduling tools, or accountability check-ins. Cognitive behavioral therapy (CBT) may also be used to address co-occurring symptoms such as anxiety or low self-esteem that often accompany ADHD.

Medications

Patients who don’t respond well to behavioral therapy alone may benefit from pharmacological support. Stimulants like methylphenidate or amphetamine-based treatments are most commonly prescribed. They help increase dopamine and norepinephrine activity in the brain, which supports attention, task initiation, and impulse regulation.

For some individuals, non-stimulant options like atomoxetine or guanfacine may be more appropriate. These alternatives are often considered when stimulants cause side effects or when there are specific medical concerns.

Routines

Consistent routines can make daily life more manageable for people with attention deficit disorder. Predictable schedules help reduce the mental load of decision-making and can improve follow-through on tasks like homework, chores, or work deadlines.

For school-aged children, visual schedules and clear transitions between activities can minimize frustration and increase independence. Adults often benefit from digital reminders, structured calendars, and designated workspaces that limit distractions.

TMS therapy

Transcranial magnetic stimulation (TMS) is an effective alternative for individuals who haven’t experienced meaningful improvement with traditional treatments. TMS uses focused magnetic pulses to stimulate specific areas of the brain, particularly the prefrontal cortex, which plays a central role in attention, decision-making, and self-regulation.

During a TMS session, an electromagnetic coil is placed near the scalp to deliver rapid magnetic pulses. These painless pulses activate neurons in targeted regions, potentially improving communication between underactive brain networks involved in ADHD. TMS is FDA-cleared for depression and is being studied for ADHD, with growing clinical interest in its potential to support patients with treatment-resistant symptoms. 

Explore Personalized ADHD Treatment Options

Attention-deficit/hyperactivity disorder makes the brain function differently, impacting everything from focus and routines to confidence and relationships. Fortunately, treatment options have come a long way. From behavioral strategies to non-medication therapies like TMS, care is becoming more personalized, more effective, and more supportive of each person’s experience. 

Don’t let ADHD control your life or the life of someone you care about. Contact us today to schedule a consultation and learn more about how Brain Health Center can help you take a less invasive approach to managing ADHD symptoms and improving daily functioning with TMS therapy tailored to your needs. 

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